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Overweightness and obesity are associated with many hemodynamic, structural, and histopathologic alterations in the kidney and with metabolic and biochemical changes that predispose to these abnormalities. Consequent to these disorders, these individuals are more likely to develop chronic kidney disease and end-stage renal failure. Overweight and obese people are more prone to develop albuminuria and, for at least some types of kidney disease, a greater amount of albuminuria and more rapid progression of renal failure. These individuals are more likely to develop diabetes mellitus and hypertension. Diabetic nephropathy, hypertensive nephrosclerosis, focal and segmental glomerulosclerosis, renal cell carcinoma, and urate and calcium oxalate urolithiasis are the more common kidney and urological diseases reported in obese people. Preliminary data indicate that many of the clinical and nephropathologic manifestations associated with obesity can be reversed or ameliorated with reductions in body fat induced by dietary energy restriction or surgical procedures that reduce intake and gastrointestinal absorption of calories.

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Resveratrol and cardiovascular health. Mol Aspects Med. 2010 Sep 15; Authors: Das M, Das DK Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treatment, cardiovascular disease (CVD) remains a serious clinical problem and threat to public health. Resveratrol possesses potent antioxidant properties and has been shown to decrease low-density lipoprotein-cholesterol oxidation and platelet aggregation. This compound also possesses a range of additional cardioprotective and vasoprotective properties including antiatherosclerotic and vasorelaxation action. Resveratrol also has the capacity to interact with multiple molecular targets, which involve diverse intracellular pathways. Most well-known is the ability of resveratrol to activate sirtuins, a class of NAD(+)-dependent deacetylase that affect multiple transcription factors and other protein targets. Recently, resveratrol was found to induce autophagy and regenerate myocardial ischemic tissue treated with stem cells. Overall observation indicates that resveratrol has a high therapeutic potentials for the treatment of cardiovascular diseases. PMID: 20837050 [PubMed - as supplied by publisher]

Physiological effects of resveratrol. [caption id="attachment_450" align="alignright" width="300" caption="Buy Meratol"][/caption] Biofactors. 2010 Sep;36(5):401-6 Authors: Kalantari H, Das DK Resveratrol is naturally present in certain fruits and vegetables including grape skins and especially in red wine. Similar to red wine, resveratrol possesses diverse biochemical and physiological properties including anti-inflammatory and immunomulatory activities as well as wide range of health benefits ranging from chemoprevention to cardioprotection. Recent studies implicated that resveratrol also possesses antiaging properties. The present review describes some of the important physiological properties of resveratrol that accounts for its diverse physiological actions. PMID: 20623511 [PubMed - in process]